期刊
EMBO MOLECULAR MEDICINE
卷 12, 期 7, 页码 -出版社
WILEY
DOI: 10.15252/emmm.202012421
关键词
biomarker; coronavirus disease 2019; cytokine storm; disease monitoring; interleukin-6
资金
- National Natural Science Foundation of China [81602696]
- Fundamental Research Funds for the Central Universities of China [2015QN190]
- National Science and Technology Major Project of China [2018ZX10302204-002-003]
Progression to severe disease is a difficult problem in treating coronavirus disease 2019 (COVID-19). The purpose of this study is to explore changes in markers of severe disease in COVID-19 patients. Sixty-nine severe COVID-19 patients were included. Patients with severe disease showed significant lymphocytopenia. Elevated level of lactate dehydrogenase (LDH), C-reactive protein (CRP), ferritin, and D-dimer was found in most severe cases. Baseline interleukin-6 (IL-6) was found to be associated with COVID-19 severity. Indeed, the significant increase of baseline IL-6 was positively correlated with the maximal body temperature during hospitalization and with the increased baseline of CRP, LDH, ferritin, and D-dimer. High baseline IL-6 was also associated with more progressed chest computed tomography (CT) findings. Significant decrease in IL-6 and improved CT assessment was found in patients during recovery, while IL-6 was further increased in exacerbated patients. Collectively, our results suggest that the dynamic change in IL-6 can be used as a marker for disease monitoring in patients with severe COVID-19.
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