期刊
CELLULAR & MOLECULAR IMMUNOLOGY
卷 13, 期 5, 页码 560-576出版社
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/cmi.2016.40
关键词
apoptosis; autophagy; bacterial pathogen; innate immune signaling; phagosomal maturation; ubiquitin system
类别
资金
- National Basic Research Programs of China [2012CB518700, 2014CB744400]
- National Natural Science Foundation of China [81371769, 81571954]
- Youth Innovation Promotion Association CAS [Y12A027BB2]
The ubiquitin system comprises enzymes that are responsible for ubiquitination and deubiquitination, as well as ubiquitin receptors that are capable of recognizing and deciphering the ubiquitin code, which act in coordination to regulate almost all host cellular processes, including host-pathogen interactions. In response to pathogen infection, the host innate immune system launches an array of distinct antimicrobial activities encompassing inflammatory signaling, phagosomal maturation, autophagy and apoptosis, all of which are fine-tuned by the ubiquitin system to eradicate the invading pathogens and to reduce concomitant host damage. By contrast, pathogens have evolved a cohort of exquisite strategies to evade host innate immunity by usurping the ubiquitin system for their own benefits. Here, we present recent advances regarding the ubiquitin system-mediated modulation of host-pathogen interplay, with a specific focus on host innate immune defenses and bacterial pathogen immune evasion.
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