期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 194, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2020.110454
关键词
Silver nanoparticle; Natural organic matter; Zebrafish; Bioaccumulation
资金
- Ministry of Science and Technology of China [2018YFC1801003]
- National Natural Science Foundation of China [21737003, 21876088, 41807491]
- Tianjin Municipal Science and Technology Commission [17JCYBJC23100, 16PTSYJC00020]
- Yangtze River scholar program, Ministry of Education, China [T2017002]
- 111 program, Ministry of Education, China [T2017002]
The wide application of silver nanoparticles (AgNPs) has inevitably led to their release into the natural aquatic environment. Natural organic matter (NOM) is ubiquitous and would influence the fate and effects of these nanoparticles in such aquatic environments. Here we demonstrate that NOM plays an important role in the bioaccumulation kinetics and tissue distribution of AgNPs in zebrafish. In the presence of humic acid and fulvic acid, the uptake rates of AgNPs decreased while the depuration rates of AgNPs increased. As a result, the bioconcentration factor (BCF) of AgNPs in the entire body of the zebrafish was reduced. AgNPs were mainly taken up by the zebrafish via oral ingestion and were greatly accumulated in the liver, intestine and gill. In the intestine, NOM effectively inhibited the AgNPs from penetrating the cell membranes into internal tissues and also suppressed the disintegration and dissolution of AgNPs in gastrointestinal fluid, thereby decreasing the absorption of Ag by zebrafish. This research underlines the significance of incorporating the effects of NOM into predictive models for accurately assessing the toxicity and ecological risks of nanoparticles in natural aquatic environments.
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