期刊
DYES AND PIGMENTS
卷 175, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2019.108144
关键词
Fluorescent probe; Ratiometric; Hypochlorite; Meldrum's acid; Fast response; Bioimaging
资金
- National Natural Science Foundation of China [21572177]
- Shaanxi Provincial Education Department [18JK0774]
- International Science & Technology Cooperation Program of Shaanxi Province [2019KWZ-001]
- Biomedicine Key Laboratory of Shaanxi Province [2018SZS41]
- Training Program of Innovation for Undergraduates of Northwest University [2019230]
The detection of ClO- is vital to comprehend the accurate effect of ClO- in various diseases and therapeutic interventions by fluorescent probe method. Herein, a special ratiometric probe DDD was designed and efficiently synthesized via a simple process for hypochlorite detection. The selectivity and sensitivity of probe DDD was excellent and the detection was not influenced by other reactive oxygen species. Probe DDD exhibited a fast response (<1 s), wide Stokes Shift (>100 nm), sensitive limit of detection (78 nM) and two well-separated emission (555 rim and 635 nm). The emission intensities ratio (I-555/I-635) was linearly enhanced (I-555/I-635 = 0.6273X - 1.9313) with the ClO- concentration range from 4.0 to 20.0 mu M. Furthermore, probe DDD has been successfully evaluated in monitoring exogenous HClO in SH-SY5Y neuroblastoma cells and zebrafish larvae with low cytotoxicity, good cell permeability and biocompatibility.
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