期刊
DOSE-RESPONSE
卷 18, 期 2, 页码 -出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1559325820928687
关键词
miR-527; esophageal squamous cell carcinoma; PHLPP2; cell proliferation; cell cycle
资金
- Department of Surgical Oncology (Thoracic Tumor), Xinxiang Central Hospital
Increasing evidence indicated that microRNAs served dominant roles in carcinogenesis and cancer progression by targeting potential downstream genes. In our study, we found that miR-527 was an upregulated expression in human esophageal squamous cell carcinoma (ESCC) cells and tissues. Furthermore, overexpression of miR-527 promoted cell proliferation and colony formation, enhanced anchorage-independent growth ability, and contributed to cell cycle. In addition, protein phosphatase 2 (PHLPP2) was identified as the direct downstream target gene of miR-527 and was confirmed by luciferase gene reporter assay. In summary, we concluded that miR-527 acted as an oncogenic microRNA in ESCC development by directly targeting PHLPP2 might be a novel therapeutic target for the treatment of ESCC.
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