期刊
CELL STEM CELL
卷 18, 期 1, 页码 25-38出版社
CELL PRESS
DOI: 10.1016/j.stem.2015.12.005
关键词
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资金
- National Institutes of Health [HL095722]
- NIH [DE013023]
- Kenneth Rainin Foundation Break-through Award
- Movember Prostate Cancer Foundation
- Charles A. King Trust
- William Randolph Hearst BWH DOM Young Investigator Award
- NSF
Organoid systems leverage the self-organizing properties of stem cells to create diverse multi-cellular tissue proxies. Most organoid models only represent single or partial components of a tissue, and it is often difficult to control the cell type, organization, and cell-cell/cell-matrix interactions within these systems. Herein, we discuss basic approaches to generate stem cell-based organoids, their advantages and limitations, and how bioengineering strategies can be used to steer the cell composition and their 3D organization within organoids to further enhance their utility in research and therapies.
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