期刊
DIABETOLOGIA
卷 63, 期 7, 页码 1408-1417出版社
SPRINGER
DOI: 10.1007/s00125-020-05146-z
关键词
Clinical diabetes; Epidemiology; Human; Microvascular disease; Pathogenic mechanism; Pathophysiology; metabolism
资金
- European Regional Development Fund via OP-Zuid
- Province of Limburg
- Dutch Ministry of Economic Affairs [31O.041]
- Stichting De Weijerhorst (Maastricht, the Netherlands)
- Pearl String Initiative Diabetes (Amsterdam, the Netherlands)
- CARIM, School for Cardiovascular Diseases (Maastricht, the Netherlands)
- School CAPHRI, Care and Public Health Research Institute (Maastricht, the Netherlands)
- NUTRIM, School of Nutrition and Translational Research in Metabolism (Maastricht, the Netherlands)
- Stichting Annadal (Maastricht, the Netherlands)
- Health Foundation Limburg (Maastricht, the Netherlands)
- Janssen-Cilag B.V. (Tilburg, the Netherlands)
- Novo Nordisk Farma B.V. (Alphen aan den Rijn, the Netherlands)
- Sanofi-Aventis Netherlands B.V. (Gouda, the Netherlands)
- Chinese Scholarship Council [201606260039]
Aims/hypothesis Retinal microvascular diameters are biomarkers of cardio-metabolic risk. However, the association of (pre)diabetes with retinal microvascular diameters remains unclear. We aimed to investigate the association of prediabetes (impaired fasting glucose or impaired glucose tolerance) and type 2 diabetes with retinal microvascular diameters in a predominantly white population. Methods In a population-based cohort study with oversampling of type 2 diabetes (N = 2876; n = 1630 normal glucose metabolism [NGM], n = 433 prediabetes and n = 813 type 2 diabetes, 51.2% men, aged 59.8 +/- 8.2 years; 98.6% white), we determined retinal microvascular diameters (measurement unit as measured by retinal health information and notification system [RHINO] software) and glucose metabolism status (using OGTT). Associations were assessed with multivariable regression analyses adjusted for age, sex, waist circumference, smoking, systolic blood pressure, lipid profile and the use of lipid-modifying and/or antihypertensive medication. Results Multivariable regression analyses showed a significant association for type 2 diabetes but not for prediabetes with arteriolar width (vs NGM; prediabetes: beta = 0.62 [95%CI -1.58, 2.83]; type 2 diabetes: 2.89 [0.69, 5.08]; measurement unit); however, there was a linear trend for the arteriolar width across glucose metabolism status (p for trend = 0.013). The association with wider venules was not statistically significant (prediabetes: 2.40 [-1.03, 5.84]; type 2 diabetes: 2.87 [-0.55, 6.29], p for trend = 0.083; measurement unit). Higher HbA(1c) levels were associated with wider retinal arterioles (standardised beta = 0.043 [95% CI 0.00002, 0.085]; p = 0.050) but the association with wider venules did not reach statistical significance (0.037 [-0.006, 0.080]; p = 0.092) after adjustment for potential confounders. Conclusions/interpretation Type 2 diabetes, higher levels of HbA(1c) and, possibly, prediabetes, are independently associated with wider retinal arterioles in a predominantly white population. These findings indicate that microvascular dysfunction is an early phenomenon in impaired glucose metabolism.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据