期刊
CELL STEM CELL
卷 18, 期 6, 页码 736-748出版社
CELL PRESS
DOI: 10.1016/j.stem.2016.05.022
关键词
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资金
- Medical Research Council [MC_UP_1201/9]
- 3Rs prize from the National Centre for the Replacement, Refinement and Reduction of Animals in Research
- MRC [MC_UP_1201/9] Funding Source: UKRI
- Medical Research Council [MC_UP_1201/9] Funding Source: researchfish
Recent breakthroughs in pluripotent stem cell technologies have enabled a new class of in vitro systems for functional modeling of human brain development. These advances, in combination with improvements in neural differentiation methods, allow the generation of in vitro systems that reproduce many in vivo features of the brain with remarkable similarity. Here, we describe advances in the development of these methods, focusing on neural rosette and organoid approaches, and compare their relative capabilities and limitations. We also discuss current technical hurdles for recreating the cell-type complexity and spatial architecture of the brain in culture and offer potential solutions.
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