期刊
CELL STEM CELL
卷 19, 期 3, 页码 298-309出版社
CELL PRESS
DOI: 10.1016/j.stem.2016.06.017
关键词
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资金
- Ministry of Economy and Competitiveness (Government of Spain)
- Max Planck Society
The ability to reprogram somatic cells into induced pluripotent stem cells (iPSCs) using defined factors provides new tools for biomedical research. However, some iPSC clones display tumorigenic and immunogenic potential, thus raising concerns about their utility and safety in the clinical setting. Furthermore, variability in iPSC differentiation potential has also been described. Here we discuss whether these therapeutic obstacles are specific to transcription-factor-mediated reprogramming or inherent to every cellular reprogramming method. Finally, we address whether a better understanding of the mechanism underlying the reprogramming process might improve the fidelity of reprogramming and, therefore, the iPSC quality.
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