A Gli(1)ttering Role for Perivascular Stem Cells in Blood Vessel Remodeling

Blood vessels significantly remodel in response to injury and pathologic conditions, although the contribution of stem cells to this process is unclear. Now in Cell Stem Cell, Kramann et al. ( 2016) show that Gli1+ perivascular cells in the outermost vessel layer are progenitors that substantially contribute to pathologic vessel remodeling.