期刊
DEVELOPMENTAL NEUROBIOLOGY
卷 81, 期 3, 页码 300-309出版社
WILEY
DOI: 10.1002/dneu.22747
关键词
axon elongation; axon stretch growth; axonal cytoskeleton; axonal microtubules; axonal tension
资金
- Fundacao para a Ciencia e a Tecnologia [NORTE-01-0145FEDER-028623]
During development, neurons undergo polarization and axon growth, which require the integration of external and internal signals. Membrane remodeling and cytoskeleton dynamics play crucial roles in guiding growth cone advancement and axon elongation. After synaptic establishment, the organism's growth leads to an increased distance between neuronal cell bodies and targets.
Throughout development, neurons are capable of integrating external and internal signals leading to the morphological changes required for neuronal polarization and axon growth. The first phase of axon elongation occurs during neuronal polarization. At this stage, membrane remodeling and cytoskeleton dynamics are crucial for the growth cone to advance and guide axon elongation. When a target is recognized, the growth cone collapses to form the presynaptic terminal. Once a synapse is established, the growth of the organism results in an increased distance between the neuronal cell bodies and their targets. In this second phase of axon elongation, growth cone-independent molecular mechanisms and cytoskeleton changes must occur to enable axon growth to accompany the increase in body size. While the field has mainly focused on growth-cone mediated axon elongation during development, tension driven axon growth remains largely unexplored. In this review, we will discuss in a critical perspective the current knowledge on the mechanisms guiding axon growth following synaptogenesis, with a particular focus on the putative role played by the axonal cytoskeleton.
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