期刊
DEVELOPMENTAL NEUROBIOLOGY
卷 81, 期 3, 页码 310-320出版社
WILEY
DOI: 10.1002/dneu.22753
关键词
astrocytes; cytoskeleton; glia; glioma; microglia; microtubules; oligodendrocytes
资金
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- Vincent J. Coates Research Foundation
- Myra Reinhard Foundation
This review provides an overview of the literature on microtubules in ramified brain cells, focusing on their importance in different types of glial cells and how structure relates to function in these cells. Research shows that microtubules play important roles in glial cells, particularly in oligodendrocytes for extension of processes and myelin sheath elongation.
Though much is known about microtubule organization and microtubule-based transport in neurons, the development and function of microtubules in glia are more enigmatic. In this review, we provide an overview of the literature on microtubules in ramified brain cells, including oligodendrocytes, astrocytes, and microglia. We focus on normal cell biology-how structure relates to function in these cells. In oligodendrocytes, microtubules are important for extension of processes that contact axons and for elongating the myelin sheath. Recent studies demonstrate that new microtubules can form outside of the oligodendrocyte cell body off of Golgi outpost organelles. In astrocytes and microglia, changes in cell shape and ramification can be influenced by neighboring cells and the extracellular milieu. Finally, we highlight key papers implicating glial microtubule defects in neurological injury and disease and discuss how microtubules may contribute to invasiveness in gliomas. Thus, future research on the mechanisms underlying microtubule organization in normal glial cell function may yield valuable insights on neurological disease pathology.
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