期刊
DEVELOPMENT
卷 147, 期 9, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.182279
关键词
Angiogenesis; Blood-brain barrier; Blood-retina barrier; Neurovascular unit; Basement membrane; Neuroglial progenitors; Neuronal activity; Radial glia; Astrocytes; Muller glia; Retinal waves; Light response
资金
- National Institutes of Health [R01 MH112849, R01 NS107344, RF1 AG054023]
- Fondation Leducq [FDNLEDQ15CVD-02]
- National Multiple Sclerosis Society [RG-1901-33218]
Neurovascular pathologies of the central nervous system (CNS), which are associated with barrier dysfunction, are leading causes of death and disability. The roles that neuronal and glial progenitors and mature cells play in CNS angiogenesis and neurovascular barrier maturation have been elucidated in recent years. Yet how neuronal activity influences these processes remains largely unexplored. Here, we discuss our current understanding of how neuronal and glial development affects CNS angiogenesis and barriergenesis, and outline future directions to elucidate how neuronal activity might influence these processes. An understanding of these mechanisms is crucial for developing new interventions to treat neurovascular pathologies.
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