期刊
DERMATOLOGIC THERAPY
卷 33, 期 4, 页码 -出版社
WILEY
DOI: 10.1111/dth.13672
关键词
cutaneous SCC; immunotherapy; nivolumab; PD-1; PD-L1
类别
Although the number of cutaneous squamous cell carcinoma (cSCC) cases is increasing, the effectiveness of systemic therapy for the treatment of advanced cSCC is limited. Since cSCC possesses a high tumor mutation burden (TMB) compared to other cancer species, and since high TMB correlated with increased neoantigens and the efficacy of anti-PD1 antibodies (Abs) in various cancers, cSCC could be a target for anti-PD1 Abs monotherapy. In this report, we describe a case of unresectable recurrent cSCC of the scalp with meningeal invasion, but highly expressedprogrammed death-ligand 1(PD-L1), treated with nivolumab monotherapy.
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