期刊
DEPRESSION AND ANXIETY
卷 37, 期 7, 页码 632-644出版社
WILEY
DOI: 10.1002/da.23009
关键词
anxiety; awareness; functional connectivity; functional magnetic resonance imaging (fMRI); generalized anxiety disorder; insula; interoception
资金
- National Key R&D Program of China [2018YFC2001605, 2019YFA0706200]
- SHSMU-ION Research Centre for Brain Disorders [2017NKX003]
- National Natural Science Foundation of China [81801345, 81071098, 81971251]
- Shanghai Municipal Natural Science Foundation [18ZR1432600, 17ZR1424700]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX03, 18411952400]
- Guangzhou Municipal Psychiatric Disease Clinical Transformation Laboratory [201805010009]
- CIHR
- UMRF
- uOBMRI
- PSI
Background Interoception is associated with neural activity in the insula of healthy humans. On the basis of the somatic symptoms in generalized anxiety disorder (GAD), especially abnormal heartbeat perception, we hypothesized that abnormal activity in the insula was associated with interoceptive awareness in patients with GAD. Methods We investigated the psychological correlates of interoceptive awareness in a sample of 34 patients with first-onset, drug-naive GAD and 30 healthy controls (HCs). Furthermore, we compared blood oxygenation level-dependent responses between the two groups during a heartbeat perception task to assess task-evoked activity and its relationship with psychological measures. We also examined between-group differences in insular subregions resting-state functional connectivity (rsFC), and its relationship with anxiety severity. Results Patients with GAD had significantly higher body perception scores than HCs. They also exhibited greater task-evoked activity in the left anterior insula, left posterior insula, and right anterior insula during interoceptive awareness than HCs. Left anterior insula activity was positively correlated with body awareness in patients with GAD, and rsFC between the left anterior insula and left medial prefrontal gyrus was negatively correlated with somatic anxiety severity. Conclusions Investigating a sample of first-episode, drug-naive patients, our study demonstrated abnormal interoceptive awareness in patients with GAD and that this was related to abnormal anterior insular activity during both rest and task. These results shed new light on the psychological and neural substrates of somatic symptoms in GAD, and they may serve to establish abnormal interoceptive awareness as a neural and psychological marker of GAD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据