期刊
CELL RESEARCH
卷 26, 期 4, 页码 457-483出版社
INST BIOCHEMISTRY & CELL BIOLOGY
DOI: 10.1038/cr.2016.40
关键词
ubiquitination; innate immunity; adaptive immunity; T cell activation; immune tolerance; autoimmunity; NF-kappa B; Peli1; TRAF
类别
资金
- US National Institutes of Health [AI057555, AI064639, GM84459, AI104519]
- Cancer Prevention and Research Institute of Texas [RP150235, RP140244]
- Thousand Young Talents Plan of China
Ubiquitination has emerged as a crucial mechanism that regulates signal transduction in diverse biological processes, including different aspects of immune functions. Ubiquitination regulates pattern-recognition receptor signaling that mediates both innate immune responses and dendritic cell maturation required for initiation of adaptive immune responses. Ubiquitination also regulates the development, activation, and differentiation of T cells, thereby maintaining efficient adaptive immune responses to pathogens and immunological tolerance to self-tissues. Like phosphorylation, ubiquitination is a reversible reaction tightly controlled by the opposing actions of ubiquitin ligases and deubiquitinases. Deregulated ubiquitination events are associated with immunological disorders, including autoimmune and inflammatory diseases.
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