期刊
CURRENT OPINION IN PEDIATRICS
卷 32, 期 2, 页码 300-307出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOP.0000000000000875
关键词
adductomics; archived dried bloodspot; biomarker; exposome; exposure; metabolomics
类别
资金
- National Institute of Environmental Health Sciences [2U2CES026561-02, 1U2CES030859-01, P30ES23515, R21ES030882-01, R21ES026776-01, U24OD023319-01]
- National Institute on Alcohol Abuse and Alcoholism [R21AA026928-02]
- National Institute of Diabetes and Digestive and Kidney Diseases [U24DK112341]
- National Institute on Aging [RF1AG057470]
Purpose of review Exposomics studies can measure health-relevant chemical exposures during a lifetime and estimate the 'internal' environment. However, sampling limitations make these features difficult to capture directly during the critical neonatal time period. Recent findings We review the use of newborn dried bloodspots (DBS) archived from newborn screening programs for exposomic analysis in epidemiological children's health studies. Emerging 'omics technologies such as adductomics and metabolomics have been adapted for DBS analysis, and these technologies can now provide valuable etiological information on the complex interplay between exposures, biological response, and population phenotypes. Adductomics and metabolomics of DBS can provide robust measurements for retrospective epidemiological investigations. With extensive bioarchiving programs in the United States and other countries, DBS are poised to substantially aid epidemiological studies, particularly for rare and low-frequency childhood diseases and disorders.
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