期刊
CURRENT BIOLOGY
卷 30, 期 14, 页码 2665-+出版社
CELL PRESS
DOI: 10.1016/j.cub.2020.04.090
关键词
-
资金
- NIH [DP2 EY025446]
- Simons Foundation SFARI Pilot Award
Cognition arises from the dynamic flow of neural activity through the brain. To capture these dynamics, we used mesoscale calcium imaging to record neural activity across the dorsal cortex of awake mice. We found that the large majority of variance in cortex-wide activity (similar to 75%) could be explained by a limited set of similar to 14 motifs'' of neural activity. Each motif captured a unique spatiotemporal pattern of neural activity across the cortex. These motifs generalized across animals and were seen in multiple behavioral environments. Motif expression differed across behavioral states, and specific motifs were engaged by sensory processing, suggesting the motifs reflect core cortical computations. Together, our results show that cortex-wide neural activity is highly dynamic but that these dynamics are restricted to a low-dimensional set of motifs, potentially allowing for efficient control of behavior.
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