期刊
CELL METABOLISM
卷 24, 期 3, 页码 434-446出版社
CELL PRESS
DOI: 10.1016/j.cmet.2016.07.023
关键词
-
资金
- European Research Council (ERC) under European Union/ERC [336607 (ERC-2013-StG-336607)]
- Louis-Jeantet Foundation
- Fondation pour Recherches Medicales
- Novartis Foundation [14B053]
- Swiss National Science Foundation (SNSF) [PP00P3_144886]
- Swiss National Science Foundation (SNF) [PP00P3_144886] Funding Source: Swiss National Science Foundation (SNF)
Caloric restriction (CR) extends lifespan from yeast to mammals, delays onset of age-associated diseases, and improves metabolic health. We show that CR stimulates development of functional beige fat within the subcutaneous and visceral adipose tissue, contributing to decreased white fat and adipocyte size in lean C57BL/6 and BALB/c mice kept at room temperature or at thermoneutrality and in obese leptin-deficient mice. These metabolic changes are mediated by increased eosinophil infiltration, type 2 cytokine signaling, and M2 macrophage polarization in fat of CR animals. Suppression of the type 2 signaling, using Il4ra(-/-), Stat6(-/-), or mice transplanted with Stat6(-/-) bone marrow-derived hematopoietic cells, prevents the CR-induced browning and abrogates the subcutaneous fat loss and the metabolic improvements induced by CR. These results provide insights into the overall energy homeostasis during CR, and they suggest beige fat development as a common feature in conditions of negative energy balance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据