Improving the cancer prevention/treatment role of carotenoids through various nano-delivery systems

One of the emerging and recent strategies to combat cancer is application of natural bioactive compounds and phytochemicals. Carotenoids including lycopene, beta-carotene, astaxanthin, crocin, beta-cryptoxanthin, and lutein, are the main group of plant pigments which play important roles in the prevention and healing process of different diseases including cancer. The pharmacological use of carotenoid compounds is frequently limited by their low bioavailability and solubility as they are mainly lipophilic compounds. The present study focuses on the current data on formulation of different carotenoid nanodelivery systems for cancer therapy and a brief overview of the obtained results. Encapsulation of carotenoids within different nanocarriers is a remarkable approach and innovative strategy for the improvement of health-promoting features and particularly, cancer prevention/treatment roles of these compounds through enhancing their solubility, cellular uptake, membrane permeation, bioaccessibility, and stability. There is various nanocarrier for loading carotenoids including polymeric/biopolymeric, lipid-based, inorganic, and hybrid nanocarriers. Almost in all relevant studies, these nano delivery systems have shown promising results in improving the efficiency of carotenoids in cancer therapy.

Automated summary

The use of natural bioactive compounds and phytochemicals, particularly carotenoids, encapsulated in nanodelivery systems is a promising strategy to enhance their efficiency in cancer therapy. Studies have shown that these nanocarriers improve the solubility, cellular uptake, membrane permeation, bioaccessibility, and stability of carotenoids, ultimately contributing to their potential roles in cancer prevention and treatment.