期刊
CELL METABOLISM
卷 24, 期 1, 页码 104-117出版社
CELL PRESS
DOI: 10.1016/j.cmet.2016.06.007
关键词
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资金
- NIH/NIAID [HHSN272201100018C]
- F. Hoffmann-La Roche Ltd.
- Glenn Foundation for Medical Research
- Ludwig center at Harvard
- European Molecular Biology Organization
- Portuguese Foundation for Science and Technology (FCT-MCTES)
Naive T cell stimulation activates anabolic metabolism to fuel the transition from quiescence to growth and proliferation. Here we show that naive CD4(+) T cell activation induces a unique program of mitochondrial biogenesis and remodeling. Using mass spectrometry, we quantified protein dynamics during T cell activation. We identified substantial remodeling of the mitochondrial proteome over the first 24 hr of T cell activation to generate mitochondria with a distinct metabolic signature, with one-carbon metabolism as the most induced pathway. Salvage pathways and mitochondrial one-carbon metabolism, fed by serine, contribute to purine and thymidine synthesis to enable T cell proliferation and survival. Genetic inhibition of the mitochondrial serine catabolic enzyme SHMT2 impaired T cell survival in culture and antigen-specific T cell abundance in vivo. Thus, during T cell activation, mitochondrial proteome remodeling generates specialized mitochondria with enhanced one-carbon metabolism that is critical for T cell activation and survival.
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