期刊
CELL METABOLISM
卷 23, 期 5, 页码 901-908出版社
CELL PRESS
DOI: 10.1016/j.cmet.2016.04.005
关键词
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资金
- Deutsche Forschungsgemeinschaft [PF 202/8-1, Sonderforschungsbereiche 746, Sonderforschungsbereiche 1140]
- Excellence Initiative of the German federal and state governments [EXC 294 BIOSS, GSC-4]
- European Research Council (ERC) [648235]
- German Academy of Sciences Leopoldina [LPDS 2013-08]
- Boehringer Ingelheim Fonds fellowship
The mitochondrial inner membrane harbors three protein translocases. Presequence translocase and carrier translocase are essential for importing nuclear-encoded proteins. The oxidase assembly (OXA) translocase is required for exporting mitochondrial-encoded proteins; however, different views exist about its relevance for nuclear-encoded proteins. We report that OXA plays a dual role in the biogenesis of nuclear-encoded mitochondrial proteins. First, a systematic analysis of OXA-deficient mitochondria led to an unexpected expansion of the spectrum of OXA substrates imported via the presequence pathway. Second, biogenesis of numerous metabolite carriers depends on OXA, although they are not imported by the presequence pathway. We show that OXA is crucial for the biogenesis of the Tim18-Sdh3 module of the carrier translocase. The export translocase OXA is thus required for the import of metabolite carriers by promoting assembly of the carrier translocase. We conclude that OXA is of central importance for the biogenesis of the mitochondrial inner membrane.
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