期刊
CORNEA
卷 39, 期 9, 页码 1112-1116出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/ICO.0000000000002337
关键词
acanthamoeba keratitis; mixed bacterial infection
资金
- Hyderabad Eye Research Foundation, Hyderabad
Purpose: To compare the clinical profiles and outcomes of patients withAcanthamoebakeratitis with or without mixed bacterial infection. Methods: A retrospective analysis of microbiologically confirmed AK cases presenting to a tertiary care center over a 9-year period was conducted. Fourteen eyes in the coinfected group (group 1) and 24 eyes in the AK group (group 2) were analyzed to study the differences in these 2 groups of patients. The cases were diagnosed using a conventional microscopic analysis with staining techniques confirmed by cultural methods and were treated, which tailored to the microbiology report. Results: There was no difference in the demographic profile and presenting features in the 2 groups. Duration of symptoms and history of ocular trauma, contact lens wear, and previous steroid usage were also similar for both the groups. Dense central corneal infiltrate was the common presentation for both groups (7/14 vs. 16/24 in group 1 vs. group 2). Epithelial defect without dense stromal infiltrate was significantly more common in group 1 (42.9% vs. 4.2%,P= 0.003) as a presenting clinical feature. Hypopyon was present in 8/14 of group 1 versus 9/24 of group 2 eyes (P= 0.25). No significant difference was found in the final visual acuity in pure and mixed AK cases, and the need for surgical intervention was comparable. The most common bacterial pathogen isolated in the mixed group was theStaphylococcusspecies. Conclusions: Bacterial coinfection is common in patients withAcanthamoebakeratitis. Coinfection did not point toward a worse clinical disease at presentation or outcome.
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