期刊
CELL METABOLISM
卷 23, 期 5, 页码 852-866出版社
CELL PRESS
DOI: 10.1016/j.cmet.2016.04.010
关键词
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资金
- Canadian Foundation for Innovation
- Canadian Institutes of Health Research (CIHR) [MOP 125933, 133050, MOP 111226, MOP 97943]
- Canadian HIV Cure Enterprise Team Grant [HIG-133050]
- National Research Foundation of Korea (NRF) - Korean government (the Ministry of Science, ICT and Future Planning) [NRF-2013S1A2A2035348, 2013M3A9D5072550, 2012R1A3A2026454, 2015M3A9B6029138, 2010-0020878, 2010-0019866]
- CIHR
- National Research Foundation of Korea [2015M3A9B6029138, 2010-0020878, 2010-0019866, 2013S1A2A2035348] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Plasmacytoid dendritic cells (pDCs) are unique bone-marrow-derived cells that produce large amounts of type I interferon in response to microbial stimulation. Furthermore, pDCs also promote T cell tolerance in sterile-inflammation conditions. However, the immunomodulatory role of aortic pDCs in atherosclerosis has been poorly understood. Here, we identified functional mouse and human pDCs in the aortic intima and showed that selective, inducible pDC depletion in mice exacerbates atherosclerosis. Aortic pDCs expressed CCR9 and indoleamine 2,3-dioxygenase 1 (IDO-1), an enzyme involved in driving the generation of regulatory T cells (Tregs). As a consequence, loss of pDCs resulted in decreased numbers of Tregs and reduced IL-10 levels in the aorta. Moreover, antigen presentation by pDCs expanded antigen-specific Tregs in the atherosclerotic aorta. Notably, Tregs ablation affected pDC homeostasis in diseased aorta. Accordingly, pDCs in human atherosclerotic aortas colocalized with Tregs. Collectively, we identified a mechanism of atheroprotection mediated by tolerogenic aortic pDCs.
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