期刊
CELL HOST & MICROBE
卷 19, 期 5, 页码 696-704出版社
CELL PRESS
DOI: 10.1016/j.chom.2016.04.013
关键词
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资金
- Task-Force of Zika Virus Research from the Chinese Academy of Sciences (CAS)
- Emergency Task-Force Project of the National Natural Science Foundation of China (NSFC) [81641001]
- Zika Special Project of the National Infectious Disease Control ST Grand Project
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB08020100]
- Excellent Young Scientist Program of the Chinese Academy of Sciences
- Youth Innovation Promotion Association CAS [2015078]
- Excellent Young Scientist Program from the NSFC [81522025]
- Academy of Medical Sciences, UK
- NSFC
- NSFC Innovative Research Group [81321063]
Zika virus (ZIKV), a mosquito-borne flavivirus, is a current global public health concern. The flavivirus envelope (E) glycoprotein is responsible for virus entry and represents a major target of neutralizing antibodies for other flaviviruses. Here, we report the structures of ZIKV E protein at 2.0 angstrom and in complex with a flavivirus broadly neutralizing murine antibody 2A10G6 at 3.0 angstrom. ZIKV-E resembles all the known flavivirus E structures but contains a unique, positively charged patch adjacent to the fusion loop region of the juxtaposed monomer, which may influence host attachment. The ZIKV-E-2A10G6 complex structure reveals antibody recognition of a highly conserved fusion loop. 2A10G6 binds to ZIKV-E with high affinity in vitro and neutralizes currently circulating ZIKV strains in vitro and in mice. The E protein fusion loop epitope represents a potential candidate for therapeutic antibodies against ZIKV.
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