期刊
CELL DEATH AND DIFFERENTIATION
卷 23, 期 12, 页码 1906-1918出版社
SPRINGERNATURE
DOI: 10.1038/cdd.2016.94
关键词
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资金
- NIH/NCI [1UH2TR00943-01, 1 R01 CA182905-01]
- UT MD Anderson Cancer Center SPORE in Melanoma grant from NCI [P50 CA093459]
- Aim at Melanoma Foundation
- Miriam and Jim Mulva research funds
- Brain SPORE [2P50CA127001]
- Leukemia SPORE [5P50CA100632]
- Center for radiation Oncology Research Project
- Center for Cancer Epigenetics Pilot project
- GAP MDACC grant
- CLL Moonshot pilot project
- UT MD Anderson Cancer Center Duncan Family Institute for Cancer Prevention and Risk Assessment
- SINF grant in colon cancer
- Laura and John Arnold Foundation
- RGK Foundation
- Estate of C. G. Johnson
- Ministry of National Education, CNCS-UEFISCDI project [22, PN-II-ID-PCE-2012-4-0018]
- NIH Loan Repayment Program for Clinical Research, (LRP-CR), US Department of Health and Human Services
- Fulbright-RCS research fellowship
- NIH [R01GM116184, R01GM097747, U19AI062629, R21AI113020]
- MRC [MR/K000799/1] Funding Source: UKRI
- Medical Research Council [MR/K000799/1] Funding Source: researchfish
- National Institute for Health Research [ACF-2007-26-004, CL-2015-26-003] Funding Source: researchfish
Regardless of its etiology, once septic shock is established, survival rates drop by 7.6% for every hour antibiotic therapy is delayed. The early identification of the cause of infection and prognostic stratification of patients with sepsis are therefore important clinical priorities. Biomarkers are potentially valuable clinical tools in this context, but to date, no single biomarker has been shown to perform adequately. Hence, in an effort to discover novel diagnostic and prognostic markers in sepsis, new genomic approaches have been employed. As a result, a number of small regulatory molecules called microRNAs (miRNAs) have been identified as key regulators of the inflammatory response. Although deregulated miRNA expression is increasingly well described, the pathophysiological roles of these molecules in sepsis have yet to be fully defined. Moreover, non-human miRNAs, including two Kaposi Sarcoma herpesvirus-encoded miRNAs, are implicated in sepsis and may drive enhanced secretion of pro-inflammatory and anti-inflammatory cytokines exacerbating sepsis. A better understanding of the mechanism of action of both cellular and viral miRNAs, and their interactions with immune and inflammatory cascades, may therefore identify novel therapeutic targets in sepsis and make biomarker-guided therapy a realistic prospect.
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