期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 188, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2020.110783
关键词
Titanium; Surface modification; Statherin; Protein conformation; Biological behaviors
资金
- National Key Program for Research and Development of China [2016YFC1102700]
- National Nature Science Foundation of China [31570966, 31771035]
- Cooperation program of Sichuan University and Panzhihua City, China [2018CDPZH-15]
- Fundamental Research Funds for the Central Universities, Sichuan University, China
- Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, China
The failure of dental implants is usually caused by bacteria infection, poor bioactivity and biocompatibility. It is a common phenomenon clinically. Statherin, a salivary protein, plays a crucial role of mediator between materials and cells/bacteria. However, the conformation of statherin might be changed by the implants in vivo. In this study, we investigated the effects of statherin on the bioactivities, antibacterial abilities and biocompatibilities of the titanium metals and the reaction mechanism. We found that the conformation of statherin was mainly influenced by surface composition, surface structure, surface roughness, surface hydrophilia and Ti-OH groups of materials. Statherin could decrease the cell biocompatibility of the titanium metals including pure titanium (PT), anodic oxidation (AO), sandblasting and etching (SLA) and plasma spraying hydroxyapatite (HA) coating in HGF cell experiments, regulate the bio-mineralization ability of HA coating in SBF, and enhance the antibacterial properties of PT and HA coating. This study revealed that surface properties of materials could change the conformation of statherin, which influenced the bioactivities, antibacterial properties and biocompatibilities of the materials in return.
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