Glucose sensor based on Pd nanosheets deposited on Cu/Cu2O nanocomposites by galvanic replacement

A novel non-enzymatic glucose sensor was established by galvanic replacement synthesis of Pd nanosheets (PdNS) on Cu/Cu2O nanocomposites using fluorine-doped tin oxide (FTO) substrates. To prepare PdNS-Cu/Cu2O/FTO electrode, Cu/Cu2O nanocomposites were firstly deposited on FTO electrode through potential oscillating, and then Pd nanosheets were synthesized on Cu/Cu2O nanocomposites by galvanic replacement reduction. X-ray diffraction, scanning electron microscopy, transmission electron microscopy and X-ray photoelectron spectroscopy were applied to investigate the morphology and composition of PdNS-Cu/Cu2O nanohybrids. The synthesized PdNS-Cu/Cu2O exhibited great electrochemical activity toward glucose oxidation. Under optimized conditions, the proposed glucose sensor displayed a wide linear range from 0.5 mu M to 2600 mu M with detection limit of 0.1 mu M. In addition, the proposed electrode was used to determine glucose in true blood specimen, indicating potential application for routine glucose analysis.