期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 188, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2020.110781
关键词
Humic acid; MOF; Photothermal; Controlled release; Antibacterial
资金
- Natural Science Fund of Hubei Province [2018CFA064]
- National Natural Science Foundation of China [51671081, 51871162, 51801056]
- National Outstanding Youth Science Fund [NSFC51925104]
- Hong Kong ITC [ITS/287/17, GHX/002/14SZ]
- Health and Medical Research Fund [03142446]
- Hong Kong RGC GRF [17214516]
- RGC/NSFC [N_HKU725-16]
Bacterial infection is seriously threatening human health all over the world, especially with the emergence of increasing drug-fast bacteria. It is urgent to develop a drug-free strategy to kill bacteria rapidly and efficiently. In this work, humic acid (HuA) encapsulated zeolitic imidazole framework-8 (ZIF-8) (HuA@ZIF-8) nanocomposites are synthesized by the in-situ growth of ZIF-8 on the surface of polyvinylpyrrolidone (PVP)-modified HuA. The synthesized nanocomposites possesses good photothermal effects, i.e., the temperature increased to 59.4 degrees C under the particle concentration of 1000 mu g/mL with 10 min NIR irradiation. In addition, NIR irradiation can also control the release of Zn2+ from the composites. The good photothermal effects originate from HuA that can effectively absorb NIR light. The controlled release of Zn2+ is ascribed to the induced-dissociation of ZIF-8 under NIR light irradiation. The synergistic action of photothermal therapy and release of zinc ions contributes to the excellent antibacterial efficiency of HuA@ZIF-8 within a short time, i.e. 99.59 % and 99.37 % against Staphylococcus aureus and Escherichia coli with 20 min NIR irradiation, respectively. This work provides a promising strategy to develop a light-responsive platform with good biodegradability and low cost for rapid and effective sterilization.
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