期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 189, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2020.110833
关键词
Controlled drug release; Dental resin; Dextromethorphan hydrobromide; Osmosis; Pharmacokinetic behavior
资金
- Top Young Talents Program of Hebei Province
- Scientific Research Project of Hebei Provincial High School [ZD2016136]
- Hebei Provincial Training Programs of Innovation and Entrepreneurship for Undergraduates [201810075086]
- Key Research and Development Plan of Hebei Province [19272701D]
- Post-graduate's Innovation Fund Project of Hebei University [hbu2019ss080]
The implimentation of newer technologies in drug delivery system have always been the focus of pharmaceutical scientists with advancement of technologies. In this investigation, a novel controlled-release drug-resin combination device (DRC) was designed using dental resin to control the release of dextromethorphan hydrobromide (DH). The influence of different factors on in-vitro drug release were investigated. A Box-Behnken design was used to select the optimized DRC formulation. The optimized DH loaded DRC (DH-DRC) was prepared using 59.88% of PEG400, 16 mg of dental resin and 6.64 mg of sodium chloride (NaCl). The DH releases at 2 h, 4 h and 8 h of the optimized formulation were significantly close to the predicted responses. The pharmacokinetic study in rabbits showed DH-DRC had prolonged t(max) and apparently reduced C-max compared with commercial tablets and the AUC(0-24h) of DH-DRC was slightly higher than commercial tablets. This study confirmed the novel DRC could control the release of drug. It concluded that DRC would be a promising and alternative approach for the development of controlled release dosage form.
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