期刊
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
卷 590, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfa.2020.124470
关键词
Mesoporous silica; Tetrandrine; Folic acid; Cancer therapy
资金
- Guizhou provincial science and technology department [QKHLH[2017] 7289]
- talent introduction project of Guizhou University [Gui Da Ren Ji He Zi [2019] 13]
Mesoporous silica nanoparticles with folic acid (MSN-COOH-Tet-HBP-FA) are able to mediate targeting and have a pH stimulation response character, and therefore have been successfully synthesized as vectors for antitumor drug delivery. The model drug is tetrandrine (Tel). The chemical structure and properties of these NPs were characterized through systematic characterization analyses. Their drug loading capacity was significantly improved through carboxy modification (26.86 % in max), and they exhibited pH-dependent drug release profiles(zero pre-release within 20 h in a normal physiological environment). In vitro cytotoxicity and cell uptake of the as-synthesized NPs in Hela and A549 cells were also evaluated, and exhibited high cytotoxicity and cell-targeted uptake capacity. It was concluded that MSN - COOH-Tet-HBP-FA could be used as a promising drug delivery system for cancer therapy.
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