期刊
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
卷 601, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfa.2020.124986
关键词
Pluronic F127; TPGS; Ferrocene; Brain-targeting; Electro-responsive; Controlled release
资金
- National Natural Science Foundation of China [81701267]
- Interdisciplinary Program of Shanghai Jiao Tong University [YG2016QN01]
- Development Project of Shanghai Peak Disciplines-Integrative Medicine [20150407]
- Project of Shanghai Xuhui medical research [SHXH201839]
- School of Pharmacy, Fudan University AMP
- The Open Project Program of Key Lab of Smart Drug Delivery (Fudan University), Ministry of Education, China [SDD2016-04]
Treatment efficacy for brain diseases is unsatisfactory because most drugs have low bioavailability and it's difficult for these drugs to cross the blood-brain barrier (BBB). Nanocarriers have the potential to promote drug delivery to the brain. Moreover, drug release from smart nanocarriers can be precisely controlled by responding to both exogenous and endogenous stimuli. Herein we newly constructed brain-targeting electro-responsive micelles based on Pluronic F127 and D-alpha-tocopherol polyethylene glycol succinate (TPGS) conjugated with an electro-sensitive group ferrocene (Fc) (TPGS-Fc), obtaining Pluronic F127/TPGS-Fc mixed micelles. Insoluble drugs can be encapsulated into the hydrophobic blocks of Pluronics and TPGS, as well as reduced Fc group. Because oxidation of reduced Fc by current can convert the hydrophobic group to hydrophilic one, electrical stimulation triggered micelles disassembly and corresponding drug release. The micellar carriers showed excellent biocompatibility due to the inherent safety of F127 and TPGS polymers. Fluorescent rhodamine 123- and DiR-loaded micelles demonstrated potent brain-targeting ability of the drug delivery system in vitro and in vivo, respectively. Controlled drug release responding to electrical stimulation in vivo was also confirmed by loading P2 probes (a novel water-quenching fluorescent probe). Our study revealed that the brain-targeting electro- responsive micelles have promising potential as candidate drug delivery system to the brain and warrant further assessment and development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据