期刊
CELL CYCLE
卷 15, 期 16, 页码 2124-2134出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2016.1196306
关键词
cell cycle control; cell fate specification; centrosome; degradation; proteasome
类别
资金
- American Cancer Society [RSG-11-140-01-DC]
- Roy J. Carver Charitable Trust [13-4131]
- National Science Foundation [IOS-1456941]
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1456941] Funding Source: National Science Foundation
The centrosome is the major microtubule-organizing center in animal cells but is dispensable for proper microtubule spindle formation in many biological contexts and is thus thought to fulfill additional functions. Recent observations suggest that the centrosome acts as a scaffold for proteasomal degradation in the cell to regulate a variety of biological processes including cell fate acquisition, cell cycle control, stress response, and cell morphogenesis. Here, we review the body of studies indicating a role for the centrosome in promoting proteasomal degradation of ubiquitin-proteasome substrates and explore the functional relevance of this system in different biological contexts. We discuss a potential role for the centrosome in coordinating local degradation of proteasomal substrates, allowing cells to achieve stringent spatiotemporal control over various signaling processes.
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