期刊
CNS NEUROSCIENCE & THERAPEUTICS
卷 26, 期 9, 页码 962-971出版社
WILEY
DOI: 10.1111/cns.13387
关键词
Alzheimer's disease; dynamic; state; temporal variability
资金
- National Natural Science Foundation of China (NSFC) [81601559, 61772569]
- Guangdong Basic and Applied Basic Research Foundation [2019A1515012148]
- Guangdong Provincial Natural Science Foundation of China [2016A030310233]
- Fundamental Research Funds for the Central Universities [19wkzd20]
- Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health) [U01 AG024904]
- DOD ADNI (Department of Defense) [W81XWH-12-2-0012]
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- AbbVie
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Araclon Biotech
- BioClinica, Inc
- Biogen Idec Inc
- Bristol-Myers Squibb Company
- Elan Pharmaceuticals, Inc
- Eli Lilly and Company
- EuroImmun
- F. Homann-La Roche Ltd
- Genentech, Inc
- Fujirebio
- GE Healthcare
- IXICO Ltd.
- Janssen Alzheimer Immunotherapy Research & Development, LLC.
- Johnson & Johnson Pharmaceutical Research & Development LLC.
- Medpace, Inc.
- Merck Co., Inc
- Meso Scale Diagnostics, LLC
- NeuroRx Research
- Neurotrack Technologies
- Novartis Pharmaceuticals Corporation
- Pfizer Inc
- Piramal Imaging
- Servier
- Synarc Inc
- Takeda Pharmaceutical Company
- Canadian Institutes of Health Research
- Eisai Inc
Aims Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Previous studies have demonstrated abnormalities in functional connectivity (FC) of AD under the assumption that FC is stationary during scanning. However, studies on the FC dynamics of AD, which may provide more insightful perspectives in understanding the neural mechanisms of AD, remain largely unknown. Methods Combining the sliding-window approach and the k-means algorithm, we identified three reoccurring dynamic FC states from resting-state fMRI data of 26 AD and 26 healthy controls. The between-group differences both in FC states and in regional temporal variability were calculated, followed by a correlation analysis of these differences with cognitive performances of AD patients. Results We identified three reoccurring FC states and found abnormal FC mainly in the frontal and temporal cortices. The temporal properties of FC states were changed in AD as characterized by decreased dwell time in State I and increased dwell time in State II. Besides, we found decreased regional temporal variability mainly in the somatomotor, temporal and parietal regions. Disrupted dynamic FC was significantly correlated with cognitive performances of AD patients. Conclusion Our findings suggest abnormal dynamic FC in AD patients, which provides novel insights for understanding the pathophysiological mechanisms of AD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据