期刊
CLINICAL RESEARCH IN CARDIOLOGY
卷 110, 期 1, 页码 102-113出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00392-020-01657-2
关键词
Heart failure; Sudden cardiac death; Implantable cardioverter-defibrillator; Wearable cardioverter-defibrillator
资金
- ZOLL Medical Corp. Pittsburgh, PA, USA
The WEARIT-II-EUROPE registry demonstrated that in patients with heart failure and reduced left ventricular ejection fraction, the wearable cardioverter-defibrillator (WCD) can protect against progression of ejection fraction and evaluate competing risks of potential non-arrhythmic death, potentially improving the selection for beneficial implantation of an implantable cardioverter-defibrillator.
Background The prospective WEARIT-II-EUROPE registry aimed to assess the value of the wearable cardioverter-defibrillator (WCD) prior to potential ICD implantation in patients with heart failure and reduced ejection fraction considered at risk of sudden arrhythmic death. Methods and results 781 patients (77% men; mean age 59.3 +/- 13.4 years) with heart failure and reduced left ventricular ejection fraction (LVEF) were consecutively enrolled. All patients received a WCD. Follow-up time for all patients was 12 months. Mean baseline LVEF was 26.9%. Mean WCD wearing time was 75 +/- 47.7 days, mean daily WCD use 20.3 +/- 4.6 h. WCD shocks terminated 13 VT/VF events in ten patients (1.3%). Two patients died during WCD prescription of non-arrhythmic cause. Mean LVEF increased from 26.9 to 36.3% at the end of WCD prescription (p < 0.01). After WCD use, ICDs were implanted in only 289 patients (37%). Forty patients (5.1%) died during follow-up. Five patients (1.7%) died with ICDs implanted, 33 patients (7%) had no ICD (no information on ICD in two patients). The majority of patients (75%) with the follow-up of 12 months after WCD prescription died from heart failure (15 patients) and non-cardiac death (15 patients). Only three patients (7%) died suddenly. In seven patients, the cause of death remained unknown. Conclusions Mortality after WCD prescription was mainly driven by heart failure and non-cardiovascular death. In patients with HFrEF and a potential risk of sudden arrhythmic death, WCD protected observation of LVEF progression and appraisal of competing risks of potential non-arrhythmic death may enable improved selection for beneficial ICD implantation. [GRAPHICS] .
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