期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 26, 期 9, 页码 1161-1170出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cmi.2020.04.019
关键词
Drug interaction; Dietary supplements; Herbal medicines; Vitamins; Minerals
Background: The use of complementary and alternative medicine including herbal medicine (phytotherapy), vitamins, minerals and food supplements is frequent among people living with HIV/AIDS (PLWHAs) who take antiretroviral (ARV) drugs, but is often not known by their prescribing physicians. Some drugesupplement combinations may result in clinically meaningful interactions. Aims: In this literature review, we aimed to investigate the evidence for complementary and alternative medicine interactions with ARVs. Sources: A bibliographic search of all in vitro, human studies and case reports of the PubMed database was performed to assess the risk of interactions between complementary and alternative self-medication products and ARVs. The 'HIV drug interaction' (https://www.hiv-druginteractions.org) and 'Natural medicines comprehensive database' (https:// naturalmedicines.therapeuticresearch.com) interaction checkers were also analysed. Content: St John's wort, some forms of garlic, grapefruit and red rice yeast are known to have significant interaction and thus should not be co-administered, or should be used with caution with certain ARV classes. Data on other plant-based supplements come from in vitro studies or very small size in vivo studies and are thus insufficient to conclude the real in vivo impact in case of concomitant administration with ARVs. Some polyvalent minerals such as calcium, magnesium, and iron salts can reduce the absorption of integrase inhibitors by chelation. Potential interactions with vitamin C and quercetin with some ARVs should be noted and efficacy and tolerance of the treatment should be monitored. (C) 2020 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据