期刊
CELL CYCLE
卷 15, 期 8, 页码 1084-1092出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2016.1156268
关键词
B-catenin; cancer stem cells (CSCs); E-cadherin; tumor progression; wnt-signaling
类别
资金
- Russian Science Foundation (RSCF) [14-15-00467]
- Russian Science Foundation [14-15-00467] Funding Source: Russian Science Foundation
Here we show that cancer stem cells amount in human lung adenocarcinoma cell line A549 depends on E-cadherin expression. In fact, downregulation of E-cadherin expression enhanced expression of pluripotent genes (c-MYC, NESTIN, OCT3/4 and SOX2) and enriched cell population with the cells possessing the properties of so-called cancer stem cells' via activation of Wnt/-catenin signaling. Repression of E-cadherin also stimulated cell proliferation and migration in vitro, decreased cell amount essential for xenografts formation in nude mice, increased tumors vascularization and growth. On the other hand, E-cadherin upregulation caused opposite effects i.e. diminished the number of cancer stem cells, decreased xenograft vascularization and decelerated tumor growth. Therefore, agents restoring E-cadherin expression may be useful in anticancer therapy.
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