期刊
CELL CYCLE
卷 15, 期 18, 页码 2410-2413出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2016.1215388
关键词
diagnostic marker; esophageal cancer; HMGA based therapy; HMGA proteins; malignant phenotype
类别
We have recently shown that HMGA2 is overexpressed in esophageal squamous cell carcinoma (ESCC) and its detection allows to discriminate between cancer and normal surrounding tissue proposing HMGA2 as a novel diagnostic marker. Interestingly, esophageal adenocarcinoma shows an opposite behavior with the overexpression of HMGA1 but not HMGA2. Moreover, we show that the suppression of HMGA2 in 2 ESCC cell lines reduces the malignant phenotype. Then, this paper highlights a differential induction of the HMGA proteins, depending on the cancer histological type, and reinforces the perspective of an innovative esophageal cancer therapy based on the suppression of the HMGA protein function and/or expression.
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