期刊
CELL COMMUNICATION AND SIGNALING
卷 14, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12964-015-0125-7
关键词
Membrane-less organelles; Phase separation; Multivalency; Stress response; RNA metabolism
类别
资金
- NIH [1R01GM115634]
- National Cancer Institute Cancer Center [P30CA21765]
- ALSAC
Inside eukaryotic cells, macromolecules are partitioned into membrane-bounded compartments and, within these, some are further organized into non-membrane-bounded structures termed membrane-less organelles. The latter structures are comprised of heterogeneous mixtures of proteins and nucleic acids and assemble through a phase separation phenomenon similar to polymer condensation. Membrane-less organelles are dynamic structures maintained through multivalent interactions that mediate diverse biological processes, many involved in RNA metabolism. They rapidly exchange components with the cellular milieu and their properties are readily altered in response to environmental cues, often implicating membrane-less organelles in responses to stress signaling. In this review, we discuss: (1) the functional roles of membrane-less organelles, (2) unifying structural and mechanistic principles that underlie their assembly and disassembly, and (3) established and emerging methods used in structural investigations of membrane-less organelles.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据