期刊
CLINICAL CANCER RESEARCH
卷 26, 期 16, 页码 4390-4401出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-19-3104
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资金
- SPORE for Translational Approaches to Brain Cancer [1R01NS110703-01A1, 5DP5OD021356-05, P50CA221747]
- Robert H. Lurie Cancer Center Support Grant [P30CA060553]
- Lou and Jean Malnati Brain Tumor Institute
- Matthew Larson Foundation Iron Matt Research Award
- NCI [P30-CA060553]
Purpose: Cancer immunoediting shapes tumor progression by the selection of tumor cell variants that can evade immune recognition. Given the immune evasion and intratumor heterogeneity characteristic of gliomas, we hypothesized that CD8(+) T cells mediate immunoediting in these tumors. Experimental Design: We developed retrovirus-induced PDGF(+)Pten(-/-) murine gliomas and evaluated glioma progression and tumor immunogenicity in the absence of CD8(+) T cells by depleting this immune cell population. Furthermore, we characterized the genomic alterations present in gliomas that developed in the presence and absence of CD8(+) T cells. Results: Upon transplantation, gliomas that developed in the absence of CD8(+) T cells engrafted poorly in recipients with intact immunity but engrafted well in those with CD8(+) T-cell depletion. In contrast, gliomas that developed under pressure from CD8(+) T cells were able to fully engraft in both CD8(+) T-cell-depleted mice and immunocompetent mice. Remarkably, gliomas developed in the absence of CD8(+) T cells exhibited increased aneuploidy, MAPK pathway signaling, gene fusions, and macrophage/ microglial infiltration, and showed a proinflammatory phenotype. MAPK activation correlated with macrophage/microglia recruitment in this model and in the human disease. Conclusions: Our studies indicate that, in these tumormodels, CD8(+) T cells influence glioma oncogenic pathways, tumor genotype, and immunogenicity. This suggests immunoediting of immunogenic tumor clones through their negative selection by CD8(+) T cells during glioma formation.
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