期刊
CLINICAL CANCER RESEARCH
卷 26, 期 15, 页码 3947-3957出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-19-3953
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资金
- AstraZeneca
- Cancer Research UK
- Experimental Cancer Medicine Centre
- Biomedical Research Centre grants
- NCI Cancer Center Support Grant [CCSG P30 CA08748]
- BCRF
- National Institutes of Health Research Professorship award [RP-201607-028]
Purpose: The activating mutation AKT1(E17K) occurs in approximately 7% of estrogen receptor-positive (ER+) metastatic breast cancer (MBC). We report, from a multipart, first-in-human, phase I study (NCT01226316), tolerability and activity of capivasertib, an oral AKT inhibitor, as monotherapy or combined with fulvestrant in expansion cohorts of patients with AKT1(E17K)-mutant ER+ MBC. Patients and Methods: Patients with an AKT1E17K mutation, detected by local (next-generation sequencing) or central (plasma-based BEAMing) testing, received capivasertib 480 mg twice daily, 4 days on, 3 days off, weekly or 400 mg twice daily combined with fulvestrant at the labeled dose. Study endpoints included safety, objective response rate (ORR; RECIST v1.1), progression-free survival (PFS), and clinical benefit rate at 24 weeks (CBR24). Biomarker analyses were conducted in the combination cohort. Results: From October 2013 to August 2018, 63 heavily pretreated patients received capivasertib (20 monotherapy, 43 combination). ORR was 20% with monotherapy, and within the combination cohort was 36% in fulvestrant-pretreated and 20% in fulvestrant-naive patients, although the latter group may have had more aggressive disease at baseline. AKT1(E17K) mutations were detectable in plasma by BEAMing (95%, 41/43), droplet digital PCR (80%, 33/41), and next-generation sequencing (76%, 31/41). A >= 50% decrease in AKT1(E17K) at cycle 2 day 1 was associated with improved PFS. Combination therapy appeared more tolerable than monotherapy [most frequent grade >= 3 adverse events: rash (9% vs. 20%), hyperglycemia (5% vs. 30%), diarrhea (5% vs. 10%)]. Conclusions: Capivasertib demonstrated clinically meaningful activity in heavily pretreated patients with AKT1(E17K)-mutant ER+ MBC, including those with prior disease progression on fulvestrant. Tolerability and activity appeared improved by the combination.
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