期刊
CLINICA CHIMICA ACTA
卷 503, 期 -, 页码 145-150出版社
ELSEVIER
DOI: 10.1016/j.cca.2020.01.013
关键词
cfDNA; Inflammation; Cardiovascular disease; MMPs
资金
- National Institute of Health (NIDDK) [R00DK105160]
- NIDA [U54DA016511]
- Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development Award [IK2BX003922]
- 2019 S&R Foundation Ryuji Ueno Award by the American Physiological Society
Release of cell free DNA (cfDNA) from damaged or dead cells routinely occurs in normal physiology. Recently, cfDNA has emerged as an essential biomarker in cardiovascular disease (CVD) of potential prognostic and diagnostic significance. Within the last decade, significant research efforts have been devoted to uncovering the mechanisms mediating cfDNA release and its outcome-predicting ability. The current review focuses on the pathways for cfDNA release in myocardial infarction, heart failure and hypertension, and discusses implementation of cfDNA monitoring to assess the overall development of these disease states and predict future complications.
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