期刊
CIRCULATION RESEARCH
卷 126, 期 9, 页码 1112-1126出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.119.315940
关键词
atherosclerosis; cardiovascular disease; immunology; phenotype; transcriptomic
资金
- National Institutes of Health [R01 HL121697, P01 HL136275, P01 HL088093]
- DFG from the German government [GZ WI 4811/1-1]
- NIH [R00 HL138163]
- Government of the Russian Federation [0808]
- Skoltech
Technological advances in characterizing molecular heterogeneity at the single cell level have ushered in a deeper understanding of the biological diversity of cells present in tissues including atherosclerotic plaques. New subsets of cells have been discovered among cell types previously considered homogenous. The commercial availability of systems to obtain transcriptomes and matching surface phenotypes from thousands of single cells is rapidly changing our understanding of cell types and lineage identity. Emerging methods to infer cellular functions are beginning to shed new light on the interplay of components involved in multifaceted disease responses, like atherosclerosis. Here, we provide a technical guide for design, implementation, assembly, and interpretations of current single cell transcriptomics approaches from the perspective of employing these tools for advancing cardiovascular disease research.
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