期刊
CELL BIOLOGY AND TOXICOLOGY
卷 32, 期 2, 页码 133-139出版社
SPRINGER
DOI: 10.1007/s10565-016-9326-0
关键词
LMX1A; Gastric cancer; Metastasis; beta-catenin
资金
- Natural Science Foundation of Shanghai [134119b2600]
- Natural Science Foundation of Minhang District [2014MHZ062]
Previously, we reported that the LIM homeobox transcription factor 1, alpha (LMX1A) presented tumor-suppressing roles in gastric AGS cells. Here, we showed that LMX1A also inhibits metastasis-related behaviors including migration and invasion of gastric cancer cells. Mechanistic study revealed that the role of LMX1A was mediated by beta-catenin, as knockdown of LMX1A upregulated the expression of beta-catenin and knockdown of beta-catenin reversed the effects of LMX1A silencing. beta-catenin is essential for the activation of WNT signaling pathway. Indeed, knockdown of LMX1A activated the expressions of WNT signaling target genes T cell-specific transcription factor 4 (TCF4) and matrix metalloproteinase-7 (MMP7). What is more, the expression of LMX1A was negatively correlated with WNT signaling target genes in two datasets of human gastric cancer tissues. Thus, our study revealed an anti-metastatic role of LMX1A in gastric cancer which is mediated by the negative regulation of beta-catenin signaling target genes.
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