4.4 Review

From obesity to cancer: a review on proposed mechanisms

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Metabolic syndrome and risk of cancer: Which link?

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Review Endocrinology & Metabolism

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Review Pharmacology & Pharmacy

Targeting the TGFβ pathway for cancer therapy

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PHARMACOLOGY & THERAPEUTICS (2015)

Review Chemistry, Medicinal

Siltuximab (CNTO 328): a promising option for human malignancies

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DRUG DESIGN DEVELOPMENT AND THERAPY (2015)

Article Endocrinology & Metabolism

Obesity and cancer pathogenesis

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Review Nutrition & Dietetics

Macrophages and the Regulation of Adipose Tissue Remodeling

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ANNUAL REVIEW OF NUTRITION, VOL 34 (2014)

Article Oncology

A Web Tool for Age-Period-Cohort Analysis of Cancer Incidence and Mortality Rates

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Review Biochemistry & Molecular Biology

The Role of Monoacylglycerol Lipase (MAGL) in the Cancer Progress

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CELL BIOCHEMISTRY AND BIOPHYSICS (2014)

Article Oncology

Exogenous fatty acid binding protein 4 promotes human prostate cancer cell progression

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INTERNATIONAL JOURNAL OF CANCER (2014)

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Angiopoietins in inflammation and their implication in the development of inflammatory bowel disease. A review

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Article Oncology

Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer

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MOLECULAR CANCER THERAPEUTICS (2014)

Review Endocrinology & Metabolism

Obesity and cancer-mechanisms underlying tumour progression and recurrence

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NATURE REVIEWS ENDOCRINOLOGY (2014)

Review Biochemistry & Molecular Biology

Epithelial ovarian cancer experimental models

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ONCOGENE (2014)

Review Oncology

The relevance of the TGF-β Paradox to EMT-MET programs

Chevaun D. Morrison et al.

CANCER LETTERS (2013)

Review Cell Biology

Cellular Fatty Acid Metabolism and Cancer

Erin Currie et al.

CELL METABOLISM (2013)

Review Medical Laboratory Technology

Adipokines in obesity

Viviane de Oliveira Leal et al.

CLINICA CHIMICA ACTA (2013)

Review Biochemistry & Molecular Biology

Smad phospho-isoforms direct context-dependent TGF-β signaling

Koichi Matsuzaki

CYTOKINE & GROWTH FACTOR REVIEWS (2013)

Review Cell Biology

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development

Franziska Baenke et al.

DISEASE MODELS & MECHANISMS (2013)

Review Endocrinology & Metabolism

Leptin's Role in Lipodystrophic and Nonlipodystrophic Insulin-Resistant and Diabetic Individuals

Hyun-Seuk Moon et al.

ENDOCRINE REVIEWS (2013)

Review Oncology

Insulin resistance and cancer: the role of insulin and IGFs

Sefirin Djiogue et al.

ENDOCRINE-RELATED CANCER (2013)

Review Biochemistry & Molecular Biology

Lessons from Mouse Models of High-Fat Diet-Induced NAFLD

Akinobu Nakamura et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Article Biochemistry & Molecular Biology

Cytokine Response Is Determined by Duration of Receptor and Signal Transducers and Activators of Transcription 3 (STAT3) Activation

David A. Braun et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Oncology

Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers

Rakesh K. Jain

JOURNAL OF CLINICAL ONCOLOGY (2013)

Review Endocrinology & Metabolism

Role of adipokines in cardiovascular disease

Harman S. Mattu et al.

JOURNAL OF ENDOCRINOLOGY (2013)

Review Endocrinology & Metabolism

Global obesity: trends, risk factors and policy implications

Vasanti S. Malik et al.

NATURE REVIEWS ENDOCRINOLOGY (2013)

Article Multidisciplinary Sciences

Diet-Induced Obesity Promotes Colon Tumor Development in Azoxymethane-Treated Mice

Iina Tuominen et al.

PLOS ONE (2013)

Article Endocrinology & Metabolism

Loss of adipocyte specification and necrosis augment tumor-associated inflammation

Marek Wagner et al.

ADIPOCYTE (2013)

Article Oncology

Obesity, metabolic dysregulation, and cancer: a growing concern and an inflammatory (and microenvironmental) issue

Stephen D. Hursting et al.

NUTRITION AND PHYSICAL ACTIVITY IN AGING, OBESITY, AND CANCER (2012)

Article Oncology

Obesity and cancer risk: evidence, mechanisms, and recommendations

Ivana Vucenik et al.

NUTRITION AND PHYSICAL ACTIVITY IN AGING, OBESITY, AND CANCER (2012)

Review Endocrinology & Metabolism

Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implications

Gilberto Paz-Filho et al.

ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA (2012)

Review Pharmacology & Pharmacy

Adiponectin and cardiovascular health: an update

Xiaoyan Hui et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

Article Oncology

Nutrition and Physical Activity Guidelines for Cancer Survivors

Cheryl L. Rock et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2012)

Review Endocrinology & Metabolism

Sex Differences and Sex Steroids in Lung Health and Disease

Elizabeth A. Townsend et al.

ENDOCRINE REVIEWS (2012)

Review Endocrinology & Metabolism

The Role of Adiponectin in Cancer: A Review of Current Evidence

Maria Dalamaga et al.

ENDOCRINE REVIEWS (2012)

Review Endocrinology & Metabolism

Insulin Resistance and Cancer Risk: An Overview of the Pathogenetic Mechanisms

Biagio Arcidiacono et al.

EXPERIMENTAL DIABETES RESEARCH (2012)

Review Biochemistry & Molecular Biology

Complexities of TGF-β Targeted Cancer Therapy

Erin C. Connolly et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2012)

Review Cell Biology

Progesterone receptors, their isoforms and progesterone regulated transcription

Britta M. Jacobsen et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2012)

Article Biochemistry & Molecular Biology

Obesity and pancreatic cancer: Overview of epidemiologic evidence and biologic mechanisms

Paige M. Bracci

MOLECULAR CARCINOGENESIS (2012)

Review Endocrinology & Metabolism

Minireview: The Year in Obesity and Cancer

Stephen D. Hursting

MOLECULAR ENDOCRINOLOGY (2012)

Review Cell Biology

Cancer metabolism: current perspectives and future directions

C. Munoz-Pinedo et al.

CELL DEATH & DISEASE (2012)

Article Rheumatology

Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage

Sergei I. Grivennikov et al.

ANNALS OF THE RHEUMATIC DISEASES (2011)

Review Immunology

Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease

Wenjun Ouyang et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 29 (2011)

Review Medicine, General & Internal

Regulation of vascular tone by adipocytes

Nele Maenhaut et al.

BMC MEDICINE (2011)

Review Medicine, General & Internal

Understanding the benefit of metformin use in cancer treatment

Ryan J. O. Dowling et al.

BMC MEDICINE (2011)

Article Endocrinology & Metabolism

Adipose Tissue Vascularization: Its Role in Chronic Inflammation

Jianping Ye

CURRENT DIABETES REPORTS (2011)

Review Biochemistry & Molecular Biology

The Link between the Metabolic Syndrome and Cancer

Sandra Braun et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2011)

Article Oncology

Interleukin-6 promotes tumorigenesis by altering DNA methylation in oral cancer cells

Jacqueline A. Gasche et al.

INTERNATIONAL JOURNAL OF CANCER (2011)

Review Genetics & Heredity

mTOR links oncogenic signaling to tumor cell metabolism

Jessica L. Yecies et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2011)

Review Oncology

The dynamic roles of TGF-beta in cancer

Erik Meulmeester et al.

JOURNAL OF PATHOLOGY (2011)

Review Biochemistry & Molecular Biology

Sex steroid receptors in human lung diseases

Mohit K. Verma et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2011)

Review Oncology

Esophageal and Esophagogastric Junction Cancers

Jaffer A. Ajani et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2011)

Review Biotechnology & Applied Microbiology

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

Peter Carmeliet et al.

NATURE REVIEWS DRUG DISCOVERY (2011)

Review Biotechnology & Applied Microbiology

Targeting cancer metabolism: a therapeutic window opens

Matthew G. Vander Heiden

NATURE REVIEWS DRUG DISCOVERY (2011)

Review Endocrinology & Metabolism

The economic burden of obesity worldwide: a systematic review of the direct costs of obesity

D. Withrow et al.

OBESITY REVIEWS (2011)

Article Multidisciplinary Sciences

Energy Restriction during Childhood and Early Adulthood and Ovarian Cancer Risk

Leo J. Schouten et al.

PLOS ONE (2011)

Article Surgery

Epidemiology and Economic Impact of Obesity and Type 2 Diabetes

Hazem Shamseddeen et al.

SURGICAL CLINICS OF NORTH AMERICA (2011)

Review Immunology

Adipokines in inflammation and metabolic disease

Noriyuki Ouchi et al.

NATURE REVIEWS IMMUNOLOGY (2011)

Review Endocrinology & Metabolism

Estrogen action and prostate cancer

Jason L. Nelles et al.

EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM (2011)

Review Oncology

Molecular mechanisms of cancer development in obesity

Melin J. Khandekar et al.

NATURE REVIEWS CANCER (2011)

Review Biochemistry & Molecular Biology

Metabolic genes in cancer: Their roles in tumor progression and clinical implications

Eiji Furuta et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2010)

Article Oncology

Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis

Andrea DeCensi et al.

CANCER PREVENTION RESEARCH (2010)

Article Biochemistry & Molecular Biology

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

Daniel K. Nomura et al.

Review Biochemistry & Molecular Biology

The Dual Role of Tumor Necrosis Factor (TNF) in Cancer Biology

L. Bertazza et al.

CURRENT MEDICINAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

IL-10 promotes resistance to apoptosis and metastatic potential in lung tumor cell lines

Li Zeng et al.

CYTOKINE (2010)

Review Biochemistry & Molecular Biology

Biology of interleukin-10

Robert Sabat et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2010)

Review Oncology

Fatty acid synthase as a potential therapeutic target in cancer

Richard Flavin et al.

FUTURE ONCOLOGY (2010)

Editorial Material Oncology

Biomarkers of Antiangiogenic Therapy: How Do We Move From Candidate Biomarkers to Valid Biomarkers

Dan G. Duda et al.

JOURNAL OF CLINICAL ONCOLOGY (2010)

Editorial Material Multidisciplinary Sciences

CANCER Clues from cell metabolism

William G. Kaelin et al.

NATURE (2010)

Review Biochemistry & Molecular Biology

TGF beta signaling in head and neck squamous cell carcinoma

R. A. White et al.

ONCOGENE (2010)

Article Endocrinology & Metabolism

Endothelial dysfunction in diabetes mellitus: Molecular mechanisms and clinical implications

Corey E. Tabit et al.

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2010)

Review Endocrinology & Metabolism

Unexploited therapies in breast and prostate cancer: blockade of the prolactin receptor

Eric M. Jacobson et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2010)

Review Endocrinology & Metabolism

The proliferating role of insulin and insulin-like growth factors in cancer

Emily Jane Gallagher et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2010)

Article Medicine, Research & Experimental

Mitochondrial Metabolism and Cancer

Frank Weinberg et al.

HYPOXIA AND CONSEQUENCES FROM MOLECULE TO MALADY (2009)

Review

Metabolic disturbances linked to obesity: the role of impaired tissue perfusion

Nivaldo Ribeiro Villela et al.

ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA (2009)

Editorial Material Oncology

Inflammation and Cancer: IL-6 and STAT3 Complete the Link

Jacqueline Bromberg et al.

CANCER CELL (2009)

Article Biochemistry & Molecular Biology

Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue

Nils Halberg et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

Review Multidisciplinary Sciences

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Matthew G. Vander Heiden et al.

SCIENCE (2009)

Article Oncology

Parallel progression of primary tumours and metastases

Christoph A. Klein

NATURE REVIEWS CANCER (2009)

Article Cell Biology

Connective tissue growth factor inhibits adipocyte differentiation

Joanne T. M. Tan et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2008)

Review Oncology

Role of LKB1 in lung cancer development

L. Makowski et al.

BRITISH JOURNAL OF CANCER (2008)

Review Oncology

Tumor cell metabolism: Cancer's Achilles' heel

Guido Kroemer et al.

CANCER CELL (2008)

Article Oncology

Intratumoral estrogens and estrogen receptors in human non-small cell lung carcinoma

Hiromichi Niikawa et al.

CLINICAL CANCER RESEARCH (2008)

Review Oncology

Targeting AMPK: A new therapeutic opportunity in breast cancer

Sirwan M. Hadad et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2008)

Review Oncology

Tumor necrosis factor: Renaissance as a cancer therapeutic?

D. Daniel et al.

CURRENT CANCER DRUG TARGETS (2008)

Review Cardiac & Cardiovascular Systems

The role of apelin in cardiovascular function and heart failure

Badrinathan Chandrasekaran et al.

EUROPEAN JOURNAL OF HEART FAILURE (2008)

Article Clinical Neurology

A single night of sleep deprivation increases ghrelin levels and feelings of hunger in normal-weight healthy men

Sebastian M. Schmid et al.

JOURNAL OF SLEEP RESEARCH (2008)

Review Cardiac & Cardiovascular Systems

Leptin resistance - A possible interface of inflammation and metabolism in obesity-related cardiovascular disease

Seth S. Martin et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2008)

Review Genetics & Heredity

Hypoxia and cancer

M. Christiane Brahimi-Horn et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2007)

Review Biochemistry & Molecular Biology

The emerging role of adipokines as mediators of inflammation and immune responses

Francisca Lago et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2007)

Article Cardiac & Cardiovascular Systems

Angiogenic role of LYVE-1-positive macrophages in adipose tissue

Chung-Hyun Cho et al.

CIRCULATION RESEARCH (2007)

Review Endocrinology & Metabolism

The role of the IGF system in cancer growth and metastasis: Overview and recent insights

Amir Abbas Samani et al.

ENDOCRINE REVIEWS (2007)

Review Biochemistry & Molecular Biology

The role of TNF-alpha in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk

Calin Popa et al.

JOURNAL OF LIPID RESEARCH (2007)

Review Medicine, Research & Experimental

Angiogenesis modulates adipogenesis and obesity

Yihai Cao

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Endocrinology & Metabolism

Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation

Naomi Hosogai et al.

DIABETES (2007)

Review Pharmacology & Pharmacy

Cholesterol, statins and cancer

Andrew J. Brown

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2007)

Review Multidisciplinary Sciences

Central nervous system control of food intake and body weight

G. J. Morton et al.

NATURE (2006)

Article Medicine, General & Internal

Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old

Kenneth F. Adams et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Review Biochemistry & Molecular Biology

Regulation of apoptosis by insulin-like growth factor (IGF)-I

Ron Kooijman

CYTOKINE & GROWTH FACTOR REVIEWS (2006)

Article Biochemistry & Molecular Biology

Induction of leptin resistance through direct interaction of C-reactive protein with leptin

K Chen et al.

NATURE MEDICINE (2006)

Article Urology & Nephrology

Anti-inflammatory effect of hepatocyte growth factor in chronic kidney disease: Targeting the inflamed vascular endothelium

Rujun Gong et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)

Article Gastroenterology & Hepatology

Angiogenesis as a novel component of inflammatory bowel disease pathogenesis

Silvio Danese et al.

GASTROENTEROLOGY (2006)

Review Oncology

TNF-alpha in promotion and progression of cancer

Frances Balkwill

CANCER AND METASTASIS REVIEWS (2006)

Article Biochemistry & Molecular Biology

Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner

Y Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Review Endocrinology & Metabolism

Reflections on the discovery and significance of estrogen receptor β

KF Koehler et al.

ENDOCRINE REVIEWS (2005)

Article Cardiac & Cardiovascular Systems

Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells

J Rehman et al.

CIRCULATION (2004)

Article Multidisciplinary Sciences

Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis

E Bråkenhielm et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Oncology

Obesity and cancer risk among white and black United States veterans

C Samanic et al.

CANCER CAUSES & CONTROL (2004)

Article Endocrinology & Metabolism

Adipose tissue as an endocrine organ

EE Kershaw et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2004)

Review Biochemistry & Molecular Biology

Insulin resistance in adipose tissue:: direct and indirect effects of tumor necrosis factor-α

H Ruan et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2003)

Review Endocrinology & Metabolism

Adiponectin: More than just another fat cell hormone?

M Chandran et al.

DIABETES CARE (2003)

Review Biochemistry & Molecular Biology

The ins and outs of leptin receptor activation

L Zabeau et al.

FEBS LETTERS (2003)

Article Medicine, General & Internal

Obesity, hypertension, and the risk of kidney cancer in men.

WH Chow et al.

NEW ENGLAND JOURNAL OF MEDICINE (2000)