An Easy Access to Oxime Ethers by Pd-Catalyzed C-O Cross-Coupling of Activated Aryl Bromides with Ketoximes and Chalcone Oximes

.Summary of main observation and conclusion An efficient Pd-catalyzed method for C-O cross-coupling of ketoximes and chalcone oximes with activated aryl bromides and bromo-chalcones has been developed. All oxime ethers were obtained in good to excellent yields by [(pi-allyl)PdCl](2)/tBuXPhos (L7) catalyst system. TrixiePhos (L11) was also found to be effective for the oxime coupling. This method offers an easy and smooth coupling of chalcone oximes with activated aryl bromides and bromo-chalcones, which has not been previously explored.