期刊
CHINESE JOURNAL OF CHEMISTRY
卷 38, 期 6, 页码 543-552出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.202000131
关键词
Atropisomerism; Asymmetric synthesis; Asymmetric catalysis; Chirality
资金
- NSFC [21772069, 21831007]
- Six Kinds of Talents Project of Jiangsu Province [SWYY-025]
i Summary of main observation and conclusion A new class of axially chiral aryl-alkene-indole frameworks have been designed, and the first catalytic asymmetric construction of such scaffolds has been established by the strategy of organocatalytic (Z/E)-selective and enantioselective (4+3) cyclization of 3-alkynyl-2-indolylmethanols with 2-naphthols or phenols (all >95 : 5 E/Z, up to 98% yield, 97% ee). This reaction also represents the first catalytic asymmetric construction of axially chiral alkene-heteroaryl scaffolds, which will add a new member to the atropisomeric family. This approach has not only confronted the great challenges in constructing axially chiral alkene-heteroaryl scaffolds but also provided a powerful strategy for the enantioselective construction of axially chiral aryl-alkene-indole frameworks.
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