期刊
CHINESE JOURNAL OF CHEMISTRY
卷 38, 期 11, 页码 1304-1310出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.202000166
关键词
Analytical methods; Aggregation-induced emission; Fluorescent probes; Living cells; Mouse model
资金
- NSFC [51673066, 21875069, 21574044]
- Natural Science Foundation of Guangdong Province [2016A030312002]
- Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates [2019B030301003]
of main observation and conclusion In-situoverexpressed hydrogen peroxide could serve as a biomarker for inflammation and ischemic kidney injury. Herein, a nanoprobe was developed for assay of hydrogen peroxide. The nanoprobe (TA-TPABQ) was formedviathe boronate ester groups between the hydrophilic tannic acid and the boric-acid-containing compound (TPABQ) as well as the hydrophobic interactions. The probe with good photostability shows good sensitivity and selectivity towards H2O2. The probe was adopted for identifying endogenous and exogenous H2O2 in living cells. Moreover, the probe was utilized forin vivoimaging experiments in acute abdomina and ankle inflammation mouse models as well as acute renal ischemia mouse model.
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