Mn(III)-mediated radical reaction of 2-isocyano-6-alkenyl(alkynyl) benzonitriles with arylboronic acids: Synthesis of pyrroloisoquinoline derivatives

A Mn(III) mediated radical reaction of new designed multi-functionalized 2-isocyano-6-alkenyl(alkynyl) benzonitriles with arylboronic acids has been developed. This reaction provides a method for the synthesis of pyrroloisoquinoline derivatives through the formation of two C-C bonds and one C-N bond via radical cascade cyclization in one step. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Automated summary

The study has developed a method for the synthesis of pyrroloisoquinoline derivatives through the formation of two C-C bonds and one C-N bond via radical cascade cyclization in one step.