期刊
CHINESE CHEMICAL LETTERS
卷 31, 期 9, 页码 2401-2413出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2020.03.050
关键词
Fluorine; Pharmaceuticals; Synthesis; Medicinal chemistry; Marketed medicinal drugs
资金
- National Natural Science Foundation of China [21761132021]
- IKERBASQUE, Basque Foundation for Science
- Hungarian Research Foundation (NKFIH) [K119282]
- Ministry of Human Capacities, Hungary [20391-3/2018/FEKUSTRAT]
Eleven new fluorine-containing FDA-approved drugs have been profiled and details of their discovery and preparation are discussed. Therapeutic areas include schizophrenia, migraine, multiple sclerosis, insomnia, rheumatoid arthritis, anti-tuberculosis, breast cancer, lymphoma kinase inhibitor, serotonin receptor antagonist. New pharmaceuticals feature four examples of aromatic fluorine, three aromatic CF3 group, three aliphatic CF3 and one compound with aromatic CF3O group. Furthermore, among the new compounds, six are chiral and seven are derived from tailor-made amino acids. ((C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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